TIRZEPAT

TIRZEPAT is a modern pharmaceutical-grade injectable peptide medicinal product developed in the United States and intended for medical and professional use. The product is used for the correction of disorders of carbohydrate metabolism and for body weight control in adults.

When TIRZEPAT is used:

• in type 2 diabetes mellitus to improve glycaemic control

• in cases of overweight or obesity

• in metabolic syndrome

• to reduce appetite and correct eating behavior

• when long-term maintenance of stable blood glucose levels is required

Mechanism of action:

TIRZEPAT simultaneously activates GIP and GLP-1 receptors, resulting in:

• glucose-dependent enhancement of insulin secretion

• reduction of glucagon secretion

• delayed gastric emptying

• reduction of hunger sensation and increased feeling of satiety

Due to albumin binding, the product has a prolonged half-life, allowing for once-weekly administration.

Effects during treatment:

• improved control of blood glucose levels

• reduced appetite and dietary caloric intake

• reduction in body weight due to decreased energy intake

• stabilization of metabolic parameters

• possible beneficial effects on lipid profile

Pharmaceutical quality:

• synthetic peptide with a clearly defined molecular structure

• selective activity at GIP and GLP-1 receptors

• high purity of the active substance

• stable injectable dosage form

• manufactured in accordance with GMP standards

Dosage form:

Lyophilized powder of white or almost white color for preparation of a solution for injection.

After reconstitution, a clear, colorless solution without visible particles is obtained.

Packaging: 1 vial — 10 mg.

Method of administration:

The product is intended for subcutaneous administration once weekly.

The dose is titrated gradually:

• initiation with the minimum dose

• stepwise dose escalation at intervals of no less than 4 weeks

• the maintenance dose is determined by a physician based on efficacy and tolerability

Storage conditions:

Store at a temperature of 2–8 °C, protected from light.

Do not freeze.

Follow the storage conditions specified in the manufacturer’s instructions.

Manufacturer:

American Pharmaceutical, Inc.

USA, Ohio

Important:

This product is a prescription medicinal product.

Use is permitted exclusively as prescribed by a physician after evaluation of indications and contraindications.