SEMAGLUT

SEMAGLUT is an analogue of human glucagon-like peptide-1 (GLP-1) produced using recombinant DNA technology. The medicinal product is used in medical practice for the treatment of type 2 diabetes mellitus and is known for its effects on the regulation of blood glucose levels, appetite, and body weight.

When SEMAGLUT is used:

• in patients with type 2 diabetes mellitus as an adjunct to diet and physical exercise

• to improve glycaemic control

• as part of treatment regimens aimed at reducing body weight and adipose tissue

• in patients with increased cardiovascular risk (within approved indications)

Pharmacological properties:

Semaglutide is a GLP-1 receptor agonist with high homology to the endogenous human hormone. Its mechanism of action includes:

• glucose-dependent stimulation of insulin secretion

• suppression of glucagon secretion at elevated glucose levels

• delayed gastric emptying

• reduction of appetite and caloric intake

The use of semaglutide is associated with a reduction in body weight and improvement of lipid profile parameters.

Effects during treatment:

• reduction of fasting and postprandial blood glucose levels

• improvement of glycaemic control (HbA1c)

• reduction of body weight and adipose tissue

• decreased appetite and craving for high-calorie foods

• beneficial effects on cardiovascular parameters in patients with type 2 diabetes mellitus

Pharmaceutical quality:

• recombinant analogue of human GLP-1

• high biological purity

• stable pharmaceutical dosage form

• manufactured in accordance with GMP standards

Dosage form:

Lyophilized powder of white or almost white color for preparation of a solution for injection.

After reconstitution, a clear, colorless solution without visible particles is obtained.

Packaging: 1 vial — 10 mg.

Method of administration:

The product is intended for subcutaneous administration once weekly.

The dosing regimen is determined exclusively by a physician based on the indication, the patient’s clinical condition, and response to therapy.

Storage conditions:

Store at a temperature of 2–8 °C, protected from light.

Do not freeze.

After initial use, follow the manufacturer’s recommendations.

Manufacturer:

American Pharmaceutical, Inc.

USA, Ohio

Important:

This product is a prescription medicinal product.

Use is permitted exclusively as prescribed by a physician after evaluation of indications and contraindications.

Semaglutide is not intended for the treatment of type 1 diabetes mellitus and is not a substitute for insulin.